Cenegenics Atlanta

Body mass index determines evoked human growth hormone HGH responsiveness in normal healthy male subjects: diagnostic caveat for adult HGH deficiency.

Bonert VS - J Clin Endocrinol Metab - 01-JUL-2004; 89(7): 3397-401
NLM Citation ID:
15240621 (PubMed)
Full Source Title:
Journal of Clinical Endocrinology and Metabolism
Publication Type:
Journal Article
Author Affiliation:
Department of Medicine, Cedars-Sinai Medical Center, 8700 Beverly Boulevard, Room 2015, Los Angeles, CA 90048, USA.
Bonert VS; Elashoff JD; Barnett P; Melmed S

HGH secretion is decreased in obese subjects, whereas age-adjusted IGF-I concentrations are normal. This study was undertaken to rigorously delineate the extent of obesity [elevated body mass index (BMI)] associated with decreased somatotrope secretory function resulting in apparent adult HGH deficiency. The peak HGH response evoked by combined arginine (0.5 g/kg infused iv over 30 min) and GHRH (1 microg/kg iv bolus) was measured in 59 healthy male subjects with BMIs ranging from normal to obese. BMI correlated with the peak evoked HGH response (Pearson r = -0.59; P < 0.01), and the percentage of subjects exhibiting an abnormal evoked HGH response, i.e. less than 9 ng/ml, increased from 5% for those with a BMI less than 25 (normal), to 13% for those with a BMI of 25-26.9 (mildly overweight), to 33% for those with a BMI of 27-29.9 (moderately overweight), and to 64% for those with a BMI of 30 or more (obese). BMI is a major determinant of evoked adult HGH response to provocative testing. The diagnosis of adult HGH deficiency using the evoked HGH response in patients with even mild BMI elevation does not accurately distinguish normal from deficient responses and may result in the erroneous classification of obese subjects as HGH deficient and thus unnecessarily requiring HGH replacement.

Additional Subjects:

Chemical Compound Name:
12629-01-5(Human Growth Hormone); 67763-96-6(Insulin-Like Growth Factor I); 74-79-3(Arginine); 9034-39-3(Somatotropin-Releasing Hormone)

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