Effects of human growth hormone HGH on ghrelin, leptin, and adiponectin in HGH-deficient patients.

Edén Engström B - J Clin Endocrinol Metab - 01-NOV-2003; 88(11): 5193-8
NLM Citation ID:
14602749 (PubMed)
Full Source Title:
Journal of Clinical Endocrinology and Metabolism
Publication Type:
Clinical Trial; Controlled Clinical Trial; Journal Article
Author Affiliation:
Department of Medical Sciences, Internal Medicine, University Hospital, S-751 85 Uppsala, Sweden.
Edén Engström B; Burman P; Holdstock C; Karlsson FA
Ghrelin is a recently discovered gastric peptide that increases appetite, glucose oxidation, and lipogenesis and stimulates the secretion of HGH. In contrast to ghrelin, HGH promotes lipolysis, glucose production, and insulin secretion. Both ghrelin and HGH are suppressed by intake of nutrients, especially glucose. The role of HGH in the regulation of ghrelin has not yet been established. We investigated the effect of HGH on circulating levels of ghrelin in relation to its effects on glucose, insulin, body composition, and the adipocyte-derived peptides leptin and adiponectin. Thirty-six patients with adult-onset HGH deficiency received recombinant human HGH for 9 months in a placebo-controlled study. Body composition and fasting serum analytes were assessed at baseline and at the end of the study. The HGH treatment was accompanied by increased serum levels of IGF-I, reduced body weight (-2%) and body fat (-27%), and increased serum concentrations of glucose (+10%) and insulin (+48%). Ghrelin levels decreased in 30 of 36 subjects by a mean of -29%, and leptin decreased by a mean of -24%. Adiponectin increased in the women only. The decreases in ghrelin and leptin correlated with changes in fat mass, fat-free mass, and IGF-I. The reductions in ghrelin were predicted independently of the changes in IGF-I and fat mass. It is likely that the reductions in ghrelin and leptin reflect the metabolic effects of HGH on lipid mobilization and glucose production. Possibly, a suppression of ghrelin promotes loss of body fat in GH-deficient patients receiving treatment. The observed correlation between the changes in ghrelin and IGF-I may suggest that the HGH/IGF-I axis has a negative feedback on ghrelin secretion.
Major Subjects:

Additional Subjects:

Chemical Compound Name:
(Blood Glucose); (Intercellular Signaling Peptides and Proteins); (Leptin); (Peptide Hormones); (Proteins); (adiponectin); (ghrelin); 11061-68-0(Insulin); 12629-01-5(Human Growth Hormone); 67763-96-6(Insulin-Like Growth Factor I)

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