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Five years of human growth hormone HGH replacement therapy in adults: age- and gender-related changes in isometric and isokinetic muscle strength.

Svensson J - J Clin Endocrinol Metab - 01-MAY-2003; 88(5): 2061-9
NLM Citation ID:
12727955 (PubMed)
Full Source Title:
Journal of Clinical Endocrinology and Metabolism
Publication Type:
Journal Article
Author Affiliation:
Research Centre for Endocrinology and Metabolism, Sahlgrenska University Hospital, SE-413 45 Göteborg, Sweden.
Svensson J; Stibrant Sunnerhagen K; Johannsson G
HGH replacement therapy in adults with adult-onset HGH deficiency (HGH-D) has been shown to increase isometric and isokinetic muscle strength in a few trials with limited numbers of patients. In this single center, prospective, open-label study, the effects of 5-yr HGH replacement therapy on muscle function were determined in 109 consecutive adults (61 men and 48 women) with adult-onset HGH-D. The mean initial HGH dose was 0.88 mg/d. The dose was gradually lowered, and after 5 yr the mean dose was 0.46 mg/d. The mean IGF-I SD score increased from -1.54 at baseline to 1.53 at study end. A sustained increase in lean body mass and decrease in body fat was observed. The HGH treatment induced persistent increases in isometric knee flexor strength, concentric knee flexor strength at an angular velocity of 60 degrees/sec, and right-hand peak grip strength. After correction for age and gender using observed/predicted value ratios, a sustained increase was also observed in isometric (60 degrees) and concentric (180 degrees/sec) knee extensor strength, average right-hand grip strength for 10 sec, and left-hand grip strength. At study end, knee flexor and extensor strength was 96-104% of predicted and hand grip strength was 84-90% of predicted values. The local muscle endurance was transiently decreased after correction for age and gender. No gender difference was found in the treatment responses in muscle strength. However, muscle strength (also after correction for age and gender) was lower in women than men throughout the study period. In conclusion, HGH replacement therapy in adults with adult-onset HGH-D normalized isometric and isokinetic knee flexor and extensor strength. Hand grip strength increased but was not fully normalized.
Major Subjects:

Additional Subjects:

Chemical Compound Name:
12629-01-5(Human Growth Hormone); 67763-96-6(Insulin-Like Growth Factor I)

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